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KMID : 0370220030470040206
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Yakhak Hoeji
2003 Volume.47 No. 4 p.206 ~ p.211
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Effects of Mori Folium and Crataegus pinnatifida Leave Extracts on CCl4-induced Hepatotoxicity in Rats
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김형진/Kim HJ
김증권/황완균/함인혜/권석형/황보식/김흥진/Kim JK/Whang WK/Ham IH/Kwon SH/Hwang-Bo S/Kim HJ
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Abstract
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This study was performed to investigate the effect of Mori Folium and Crataegus pinnatifida leave extracts on liver damage induced by CCl4 in rats. 30 % and 60% methanol extracts of Mori Folium and Crataegus pinnatifida leaves were administered orally at the dose of 10 mg/kg on every day for 6 days and liver damage was induced by intraperitoneal injection of CCl4 (0.4 ml/kg) on 6th day. 30% Methanol extracts of Mori Folium treated group showed significant protective effect on hepatotoxicity with the lowest Glutamic Oxaloacetic Transaminase (GOT) and Glutamic Pyruvic Transaminase (GPT). The low density lipoprotein (LDL) levels of 30% methanol extracts Mori Folium and Crataegus pinnatifida leave and 60% methanol extracts of Mori Folium treated groups were significantly lower than normal group, respectively. In articular, LDL level of 30% Mori Folium extracts treated group was significantly decreased compared to CCl4 treated group. These results support that Mori Folium and Crataegus pinnatifida leave extracts are hepatoprotective effects against hepatotoxicity induced by CCl4.
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